16052-06-5|Tricine技术资料

2021-03-17

4-(2-羟乙基)-1-哌嗪丙磺酸结构式

Tricine中文别名:N-2-羟乙基哌嗪-N’-3-丙磺酸 | 4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS) | 3-[4-(羟乙基)-1-哌嗪基]丙磺酸 | 4-(2-羟乙基)-1-哌嗪丙磺酸

 

1、4-(2-羟乙基)-1-哌嗪丙磺酸用途:

EPPS is a rescuer of A? aggregation and behavioural deficits, binding to A? aggregates and converting them into monomers.

2、4-(2-羟乙基)-1-哌嗪丙磺酸物理化学性质:

密度 1.3±0.1 g/cm3
熔点 237-239 °C(lit.)
分子式 C9H20N2O4S
分子量 252.331
精确质量 252.114380
PSA 89.46000
LogP -2.46
外观性状 白色结晶粉末
折射率 1.537
储存条件 Store at RT.
水溶解性 H2O: 1 M at 20 °C, clear, colorless
分子结构

分子性质数据:

1、 摩尔折射率:61.32

2、 摩尔体积(m3/mol):196.2

3、 等张比容(90.2K):527.2

4、 表面张力(dyne/cm):52.0

5、 极化率(10 -24cm 3):24.31

计算化学

1.疏水参数计算参考值(XlogP):-3.6

2.氢键供体数量:2

3.氢键受体数量:6

4.可旋转化学键数量:6

5.互变异构体数量:无

6.拓扑分子极性表面积89.5

7.重原子数量:16

8.表面电荷:0

9.复杂度:280

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

 

3、4-(2-羟乙基)-1-哌嗪丙磺酸文献:

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations.
J. Pharmacol. Toxicol. Methods 70(2) , 188-94, (2014)

Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation.
J. Biol. Chem. 290 , 21615-28, (2015)

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques.
Nat. Commun. 6 , 8997, (2015)

4、4-(2-羟乙基)-1-哌嗪丙磺酸英文别名:

HEPPS
3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic Acid
EINECS 240-198-8
MFCD00006160
3-[4-(2-Hydroxyethyl)-1-piperazinyl]-1-propanesulfonic acid
3-(4-(2-Hydroxyethyl)piperazin-1-yl)propane-1-sulfonic acid
4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component
1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
EPPS
4-Hydroxyerhylpiperazine-1-propanesulfonic acid