4726-96-9|O-苄基-L-丝氨酸|H-Ser(Bzl)-OH,技术参数

O-苄基-L-丝氨酸用途：

生化研究。

1.O-苄基-L-丝氨酸产品物理参数：

2.O-苄基-L-丝氨酸同类产品列表：

3.O-苄基-L-丝氨酸物理化学性质：

4.O-苄基-L-丝氨酸急救措施：

① 必要的急救措施描述：
吸入：
如果吸入,请将患者移到新鲜空气处。 如呼吸停止,进行人工呼吸。
皮肤接触：
用肥皂和大量的水冲洗。
眼睛接触：
用水冲洗眼睛作为预防措施。
食入：
切勿给失去知觉者通过口喂任何东西。 用水漱口。
② 主要症状和影响，急性和迟发效应：
据我们所知，此化学，物理和毒性性质尚未经完整的研究。

5.O-苄基-L-丝氨酸消防措施：

① 灭火介质
灭火方法及灭火剂
用水雾,抗乙醇泡沫,干粉或二氧化碳灭火。
② 源于此物质或混合物的特别的危害
碳氧化物, 氮氧化物
③ 给消防员的建议
如必要的话,戴自给式呼吸器去救火。

6.O-苄基-L-丝氨酸泄露应急处理：

① 作业人员防护措施、防护装备和应急处置程序
避免粉尘生成。 避免吸入蒸气、烟雾或气体。
② 环境保护措施
不要让产品进入下水道。
③ 泄漏化学品的收容、清除方法及所使用的处置材料
扫掉和铲掉。 放入合适的封闭的容器中待处理。

7.O-苄基-L-丝氨酸操作处置与储存：

① 安全操作的注意事项
在有粉尘生成的地方,提供合适的排风设备。一般性的防火保护措施。
② 安全储存的条件,包括任何不兼容性
贮存在阴凉处。 使容器保持密闭，储存在干燥通风处。

8.O-苄基-L-丝氨酸毒性和生态：

O-苄基-L-丝氨酸毒理学数据:

主要的刺激性影响

在皮肤上面：可能引起发炎

在眼睛上面：可能引起发炎

致敏作用：没有已知的敏化影响

O-苄基-L-丝氨酸生态学数据:

通常对水是不危害的，若无政府许可，勿将材料排入周围环境

9.O-苄基-L-丝氨酸安全信息：

10.O-苄基-L-丝氨酸海关：

11.O-苄基-L-丝氨酸文献：

Biocompatibility of poly(D,L-lactic-co-hydroxymethyl glycolic acid) microspheres after subcutaneous and subcapsular renal injection.

F Kazazi-Hyseni, J Zandstra, E R Popa, R Goldschmeding, A A R Lathuile, G J Veldhuis, C F Van Nostrum, W E Hennink, R J Kok

文献索引：Int. J. Pharm. 482(1-2) , 99-109, (2015)

全文：HTML全文

摘要

Poly(D,L-lactic-co-hydroxymethyl glycolic acid) (PLHMGA) is a biodegradable copolymer with potential as a novel carrier in polymeric drug delivery systems. In this study, the biocompatibility of PLHMGA microspheres (PLHMGA-ms) was investigated both in vitro in three different cell types (PK-84, HK-2 and PTECs) and in vivo at two implantation sites (by subcutaneous and subcapsular renal injection) in rats. Both monodisperse (narrow size distribution) and polydisperse PLHMGA-ms were prepared with volume weight mean diameter of 34 and 17 μm, respectively. Mono and polydisperse PLHMGA-ms showed good cytocompatibility properties upon 72 h incubation with the cells (100 μg microspheres/600 μL/cell line). A mild foreign body reaction was seen shortly after subcutaneous injection (20 mg per pocket) of both mono and polydisperse PLHMGA-ms with the presence of mainly macrophages, few foreign body giant cells and myofibroblasts. This transient inflammatory reaction diminished within 28 days after injection, the time-point at which the microspheres were degraded. The degradation profile is comparable to the in vitro degradation time of the microspheres (i.e., within 35 days) when incubated at 37 °C in phosphate buffered saline. Subcapsular renal injection of monodisperse PLHMGA-ms (10 mg) in rats was characterized with similar inflammatory patterns compared to the subcutaneous injection. No cortical damage was observed in the injected kidneys. In conclusion, this study demonstrates that PLHMGA-ms are well tolerated after in vivo injection in rats. This makes them a good candidate for controlled delivery systems of low-molecular weight drugs as well as protein biopharmaceuticals.Copyright © 2014 Elsevier B.V. All rights reserved.

12.O-苄基-L-丝氨酸英文别名：