6066-82-6|N-羟基琥珀酰亚胺|N-Hydroxysuccinimide,技术参数

1.N-羟基琥珀酰亚胺产品物理参数：

2.N-羟基琥珀酰亚胺同类产品列表：

3.N-羟基琥珀酰亚胺物理化学性质：

4.N-羟基琥珀酰亚胺急救措施：

① 必要的急救措施描述
吸入：
如果吸入,请将患者移到新鲜空气处。 如呼吸停止，进行人工呼吸。
皮肤接触：
用肥皂和大量的水冲洗。
眼睛接触：
谨慎起见用水冲洗眼睛。
食入：
切勿给失去知觉者喂食任何东西。 用水漱口。
② 主要症状和影响，急性和迟发效应
据我们所知，此化学，物理和毒性性质尚未经完整的研究。
③ 及时的医疗处理和所需的特殊处理的说明和指示

5.N-羟基琥珀酰亚胺消防措施：

① 灭火介质
灭火方法及灭火剂
用水雾，耐醇泡沫，干粉或二氧化碳灭火。
② 源于此物质或混合物的特别的危害
无数据资料
③ 给消防员的建议
如有必要，佩戴自给式呼吸器进行消防作业。

6.N-羟基琥珀酰亚胺泄露应急处理：

① 作业人员防护措施、防护装备和应急处置程序
避免粉尘生成。 避免吸入蒸气、气雾或气体。
② 环境保护措施
无特别的环境预防要求。
③ 泄漏化学品的收容、清除方法及所使用的处置材料
扫掉和铲掉。 放入合适的封闭的容器中待处理。

7.N-羟基琥珀酰亚胺操作处置与储存：

① 安全操作的注意事项
在有粉尘生成的地方,提供合适的排风设备。
② 安全储存的条件,包括任何不兼容性
贮存在阴凉处。 使容器保持密闭，储存在干燥通风处。对湿度敏感

8.N-羟基琥珀酰亚胺毒性和生态：

N-羟基琥珀酰亚胺生态学数据:

通常对水是不危害的，若无政府许可，勿将材料排入周围环境。

9.N-羟基琥珀酰亚胺安全信息：

10.N-羟基琥珀酰亚胺制备：

将100g（1.0mol）丁二酸酐和70g（1.0mol）盐酸羟胺一起加热，使反应系统保持负压抽除生成的挥发物，迅速加热至125℃以上，1h后慢慢升至160℃。停止加热，当温度降至125℃时，将液态反应物倾入400ml乙醚中并激烈搅拌。产物固化后倾去乙醚层，固化物与400ml丁醇共热至沸，热滤，滤液迅速冷却至0℃。1h后过滤，结晶依次用丁醇、乙醚洗涤，所得粗品用乙酸乙酯重结晶，得50g成品，收率44%。

11.N-羟基琥珀酰亚胺海关：

12.N-羟基琥珀酰亚胺文献：

Aptamer-based polyvalent ligands for regulated cell attachment on the hydrogel surface.

Erin R Gaddes, Gregory Gydush, Shihui Li, Niancao Chen, Cheng Dong, Yong Wang

文献索引：Biomacromolecules 16(4) , 1382-9, (2015)

全文：HTML全文

摘要

Natural biomolecules are often used to functionalize materials to achieve desired cell-material interactions. However, their applications can be limited owing to denaturation during the material functionalization process. Therefore, efforts have been made to develop synthetic ligands with polyvalence as alternatives to natural affinity biomolecules for the synthesis of functional materials and the control of cell-material interactions. This work was aimed at investigating the capability of a hydrogel functionalized with a novel polyvalent aptamer in inducing cell attachment in dynamic flow and releasing the attached cells in physiological conditions through a hybridization reaction. The results show that the polyvalent aptamer could induce cell attachment on the hydrogel in dynamic flow. Moreover, cell attachment on the hydrogel surface was significantly influenced by the value of shear stress. The cell density on the hydrogel was increased from 40 cells/mm(2) to nearly 700 cells/mm(2) when the shear stress was decreased from 0.05 to 0.005 Pa. After the attachment onto the hydrogel surface, approximately 95% of the cells could be triggered to detach within 20 min by using an oligonucleotide complementary sequence that displaced polyvalent aptamer strands from the hydrogel surface. While it was found that the cell activity was reduced, the live/dead staining results show that ≥98% of the detached cells were viable. Therefore, this work has suggested that the polyvalent aptamer is a promising synthetic ligand for the functionalization of materials for regulated cell attachment.

13.N-羟基琥珀酰亚胺英文别名：