29022-11-5|Fmoc-甘氨酸|Fmoc-Gly-OH,技术参数

1.Fmoc-甘氨酸产品物理参数：

2.Fmoc-甘氨酸同类产品列表：

3.Fmoc-甘氨酸物理化学性质：

4.Fmoc-甘氨酸急救措施：

① 必要的急救措施描述
吸入：
如果吸入,请将患者移到新鲜空气处。 如果停止了呼吸,给于人工呼吸。
皮肤接触：
用肥皂和大量的水冲洗。
眼睛接触：
用水冲洗眼睛作为预防措施。
食入：
切勿给失去知觉者从嘴里喂食任何东西。 用水漱口。
② 主要症状和影响，急性和迟发效应

5.Fmoc-甘氨酸 消防措施：

① 灭火介质
灭火方法及灭火剂
用水雾,耐醇泡沫,干粉或二氧化碳灭火。
② 源于此物质或混合物的特别的危害
碳氧化物, 氮氧化物
③ 给消防员的建议
如必要的话,戴自给式呼吸器去救火。

6.Fmoc-甘氨酸泄露应急处理：

① 人员的预防,防护设备和紧急处理程序
防止粉尘的生成。 防止吸入蒸汽、气雾或气体。
② 环境保护措施
不要让产物进入下水道。
③ 抑制和清除溢出物的方法和材料
扫掉和铲掉。 存放进适当的闭口容器中待处理。

7.Fmoc-甘氨酸操作处置与储存：

① 安全操作的注意事项
在有粉尘生成的地方,提供合适的排风设备。
② 安全储存的条件,包括任何不兼容性
贮存在阴凉处。 容器保持紧闭，储存在干燥通风处。
建议的贮存温度： 2 - 8 °C

8.Fmoc-甘氨酸废弃处置：

废物处理方法：
产品
将剩余的和未回收的溶液交给处理公司。
受污染的容器和包装作为未用过的产品弃置。

9.Fmoc-甘氨酸毒性和生态：

Fmoc-甘氨酸生态学数据:

通常对水是稍微有危害的，若无政府许可，勿将材料排入周围环境。

10.Fmoc-甘氨酸安全信息：

11.Fmoc-甘氨酸海关：

12.Fmoc-甘氨酸文献：

Design and solid phase synthesis of new DOTA conjugated (+)-biotin dimers planned to develop molecular weight-tuned avidin oligomers.

Alessandro Pratesi, Mauro Ginanneschi, Fabrizio Melani, Marco Chinol, Angela Carollo, Giovanni Paganelli, Marco Lumini, Mattia Bartoli, Marco Frediani, Luca Rosi, Giorgio Petrucci, Luigi Messori, Anna Maria Papini

文献索引：Org. Biomol. Chem. 13(13) , 3988-4001, (2015)

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摘要

Chemical modifications of the biotin carrier in pretargeted avidin–biotin radionuclide therapy may be of paramount importance for tuning the amount of the radioactivity delivered to cancer cells by labelled biotins. We report here the synthesis of a collection of new synthetic DOTA-constructs bearing two (+)-biotin molecules (bis-biotins), designed for the creation of multimeric Av units (tetramers) bonded to the antibody. All the syntheses were carried out following the solid phase strategy and growing the molecules on a Rink Amide resin. The biotin heads are connected through spacers containing PEG or non-PEG residues. Molecular modelling calculations suggested that the Av cross-linking ability of the bis-biotins depends mainly on the spacers length, with the best results being expected for arms affording distances in the range of 10–25 Å between the biotin carboxylate atoms, in the fully extended conformation. SEC-HPLC MALLS analysis of the products of our Av/bis-biotin reaction mixtures have confirmed this hypothesis. The bis-biotin 16, where the non-PEG linker ensured a distance of 26.7 Å between the biotin moieties, gave about 50% of Av oligomers while the shorter analogue 18 (19.5 Å) afforded 100% of an Av polymer containing about 21 protein units. Remarkably, the solubility of both the bis-biotins, i.e.16 and 18, in aqueous solutions was good and they showed excellent stability against the action of peptidases.

13.Fmoc-甘氨酸英文别名：