78081-87-5|N,N'-双芴甲氧羰基-L-赖氨酸|Fmoc-Lys(Fmoc)-OH,技术参数

1.N,N'-双芴甲氧羰基-L-赖氨酸产品物理参数：

2.N,N'-双芴甲氧羰基-L-赖氨酸同类产品列表：

3.N,N'-双芴甲氧羰基-L-赖氨酸物理化学性质：

4.N,N'-双芴甲氧羰基-L-赖氨酸急救措施：

① 必要的急救措施描述
吸入：如果吸入,请将患者移到新鲜空气处。 如果停止了呼吸,给于人工呼吸。
皮肤接触：用肥皂和大量的水冲洗。
眼睛接触：用水冲洗眼睛作为预防措施。
食入：切勿给失去知觉者从嘴里喂食任何东西。 用水漱口。
② 主要症状和影响，急性和迟发效应
③ 及时的医疗处理和所需的特殊处理的说明和指示

5.N,N'-双芴甲氧羰基-L-赖氨酸消防措施：

① 灭火介质
灭火方法及灭火剂
用水雾,耐醇泡沫,干粉或二氧化碳灭火。
② 源于此物质或混合物的特别的危害
碳氧化物, 氮氧化物
③ 给消防员的建议
如必要的话,戴自给式呼吸器去救火。

6.N,N'-双芴甲氧羰基-L-赖氨酸泄露应急处理：

① 人员的预防,防护设备和紧急处理程序
防止粉尘的生成。 防止吸入蒸汽、气雾或气体。
② 环境保护措施
不要让产物进入下水道。
③ 抑制和清除溢出物的方法和材料
扫掉和铲掉。 存放进适当的闭口容器中待处理。

7.N,N'-双芴甲氧羰基-L-赖氨酸操作处置与储存：

① 安全操作的注意事项
在有粉尘生成的地方,提供合适的排风设备。
②  安全储存的条件,包括任何不兼容性
贮存在阴凉处。 容器保持紧闭，储存在干燥通风处。
建议的贮存温度： 2 - 8 °C 充气保存

8.N,N'-双芴甲氧羰基-L-赖氨酸毒性和生态：

N,N'-双芴甲氧羰基-L-赖氨酸生态学数据:

该物质对环境可能有危害，对水体应给予特别注意。

9.N,N'-双芴甲氧羰基-L-赖氨酸安全信息：

10.N,N'-双芴甲氧羰基-L-赖氨酸文献：

Synthesis and comparative evaluation of novel (64)Cu-labeled high affinity cell-specific peptides for positron emission tomography imaging of tumor vasculature.

Joseph R Merrill, Krzysztof Krajewski, Hong Yuan, Jonathan E Frank, David S Lalush, Cam Patterson, Anka N Veleva

文献索引：Biomaterials 84 , 241-9, (2016)

全文：HTML全文

摘要

Tumor angiogenesis, the formation of new tumor blood supply, has been recognized as a hallmark of cancer and represents an important target for clinical management of various angiogenesis-dependent solid tumors. Previously, by screening a bacteriophage peptide library we have discovered the FHT-peptide sequence that binds specifically to bone marrow-derived tumor vasculature with high affinity. Here in an effort to determine the potential of the FHT-peptide for in vivo positron emission tomography (PET) imaging of aggressive tumor vasculature we studied four FHT-derivatives: NOTA-FHT, NOTA-(FHT)2, NOTA-PEG-FHT, and NOTA-PEG-(FHT)2. These peptide analogs were synthesized, labeled with the PET radionuclide (64)Cu, and characterized side-by-side with small animal PET and computed tomography imaging (microPET/CT) at 1 h, 4 h, and 24 h post injection in a subcutaneous Lewis lung carcinoma (LLC) tumor model. Because of its excellent in vivo kinetic properties and high tumor-to-background ratio, the (64)Cu-NOTA-FHT radiopeptide was selected for more detailed evaluation. Blocking studies with excess of unlabeled peptide showed specific and peptide mediated (64)Cu-NOTA-FHT tumor uptake. Biodistribution experiments in the same tumor model confirmed microPET/CT imaging results. Human radiation absorbed dose extrapolated from rodent biodistribution of (64)Cu-NOTA-FHT revealed favorable dosimetry profile. The findings from this investigation warrant further development of (64)Cu-NOTA-FHT as a potential targeted diagnostic radiopharmaceutical for PET imaging of aggressive tumor vasculature. Copyright © 2016 Elsevier Ltd. All rights reserved.

11.N,N'-双芴甲氧羰基-L-赖氨酸英文别名：