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PBS磷酸盐缓冲液(20×) 三苯基硫氯甲烷,≥96% Regorafenib (BAY 73-4506) 1-氨基芘
1.Fmoc-L-天冬氨酸产品物理参数：
2.Fmoc-L-天冬氨酸同类产品列表：
3.Fmoc-L-天冬氨酸用途： 用于生化试剂，多肽合成。
4.Fmoc-L-天冬氨酸物理化学性质：
5.Fmoc-L-天冬氨酸急救措施：
5.1 必要的急救措施描述 吸入：如果吸入,请将患者移到新鲜空气处。 如呼吸停止,进行人工呼吸。 皮肤接触：用肥皂和大量的水冲洗。 眼睛接触：用水冲洗眼睛作为预防措施。 食入：切勿给失去知觉者通过口喂任何东西。 用水漱口。 5.2 主要症状和影响，急性和迟发效应 据我们所知，此化学，物理和毒性性质尚未经完整的研究。 5.3 及时的医疗处理和所需的特殊处理的说明和指示
6.Fmoc-L-天冬氨酸消防措施：
6.1 灭火介质 灭火方法及灭火剂 用水雾,抗乙醇泡沫,干粉或二氧化碳灭火。 6.2 源于此物质或混合物的特别的危害 碳氧化物, 氮氧化物 6.3 给消防员的建议 如必要的话,戴自给式呼吸器去救火。
7.Fmoc-L-天冬氨酸泄露应急处理：
7.1 作业人员防护措施、防护装备和应急处置程序 避免粉尘生成。 避免吸入蒸气、烟雾或气体。 7.2 环境保护措施 不要让产品进入下水道。 7.3 泄漏化学品的收容、清除方法及所使用的处置材料 扫掉和铲掉。 放入合适的封闭的容器中待处理。
8.Fmoc-L-天冬氨酸操作处置与储存：
8.1 安全操作的注意事项 在有粉尘生成的地方,提供合适的排风设备。 8.2 安全储存的条件,包括任何不兼容性 贮存在阴凉处。 使容器保持密闭，储存在干燥通风处。 建议的贮存温度： -20 °C
9.Fmoc-L-天冬氨酸安全信息：
10.Fmoc-L-天冬氨酸文献：
Synthesis of N-linked glycopeptides via solid-phase aspartylation.
Trent Conroy, Katrina A Jolliffe, Richard J Payne
文献索引：Org. Biomol. Chem. 8 , 3723-3733, (2010)
全文：HTML全文
摘要
An efficient strategy for the preparation of N-linked glycopeptides is described. The method relies on the use of side chain protecting groups on aspartic acid residues, namely the allyl and Dmab esters, which are orthogonal to those utilised in Fmoc-strategy SPPS. After peptide assembly these protecting groups were selectively removed and the resulting free side chains derivatised with a glycosylamine to afford a resin bound glycopeptide bearing a native N-linkage. Initially, N-linked glycopeptides were successfully synthesised according to this strategy, however, yields varied substantially depending on the nature of the amino acid residue situated adjacent (C-terminal) to the putative glycosylation site. This was due to generation of substantial quantities of aspartimide by-products. Aspartimide formation was overcome by incorporation of a 2,4-dimethoxybenzyl (Dmb) backbone amide protecting group on the residue adjacent to an allyl- or Dmab-protected aspartic acid residue. N-linked glycopeptides were prepared in excellent yield after the solid-phase aspartylation reactions. The utility and orthogonality of the allyl and Dmab ester solid-phase approaches were exploited in the preparation of an N-linked glycodecapeptide bearing two different carbohydrate moieties. This exemplified the efficiency of the solid-phase methodology for the preparation of glycopeptides bearing various combinations of N-linked glycans.
11.Fmoc-L-天冬氨酸英文别名：
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