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PBS磷酸盐缓冲液(20×) 三苯基硫氯甲烷,≥96% Regorafenib (BAY 73-4506) 1-氨基芘
简介：3-去氮腺嘌呤，DZNep (3-Deazaneplanocin A) 是一种有效的组蛋白甲基转移酶 (histone methyltransferase，EZH2) 抑制剂。
3-去氮腺嘌呤物理化学性质：
密度
1.6±0.1 g/cm3
沸点
541.7±60.0 °C at 760 mmHg
分子式
C12H14N4O3
分子量
262.26
闪点
281.4±32.9 °C
PSA
97.19
LogP
1.48
蒸汽压
0.0±1.5 mmHg at 25°C
折射率
1.753
3-去氮腺嘌呤详细介绍：
中文名称：
3-去氮腺嘌呤
中文别名：
(1S,2R,5R)-5-(4-氨基-1H-咪唑并[4,5-C]吡啶-1-基)-3-羟甲基-3-环戊烯-1,2-二醇;3-deazaneplanocin（DzNep） 抑制剂;3-去氮腺嘌呤
英文名称：
3-Cyclopentene-1,2-diol,5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-
英文别名：
3-Cyclopentene-1,2-diol,5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-;(1S,2R,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol;3-Cyclopentene-1,2-diol,5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5...;3-DEAZANEPLANOCIN;3-Deazaneplanocin A;3-Deazaneplanocin A (DZNep, NSC 617989);3-deazaneplanocin（DzNep）;3-Deaza-neplanocin;3-Deazaneplanocin-A;AC1Q4YRK;c^Neplanocin A;DZNep;NSC 617989;SureCN863851;(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol;3-Deazaneplanocin A (DZNeP);3-Deazaneplanocin A HCl salt;NSC 617989 3-deazaneplanocin(DzNep);(1S,2R,5R)-5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyM
CAS号：
102052-95-9
分子式：
C12N4O3H14
分子量：
详细描述
创赛优选提供102052-95-9，3-去氮腺嘌呤，3-Deazaneplanocin,DZNep，Medlife，上海现货。
Medlife，致力于提供高品质、高性价比小分子化合物的产品。
Medlife小分子化合物大量库存，提供超过2万种的抑制剂、激动剂、拮抗剂等产品，是药物及疾病研究的重要原料供应商。
S-腺苷高半胱氨酸和EZH2抑制剂。
3-Deazaneplanocin A 是一种有效的组蛋白甲基转移酶 (histone methyltransferase，EZH2) 抑制剂。
查询关键词:“102052-95-9，3-去氮腺嘌呤，3-Deazaneplanocin,DZNep，PC10023，Medlife，上海现货”。
3-去氮腺嘌呤参考文献：
[1]. Fiskus W, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood, 2009, 114(13), 2733-2743.
[2]. Avan A, et al. Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells. Mol Cancer Ther. 2012 Aug;11(8):1735-46.
[3]. Kikuchi J, et al. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer. 2012 Nov;78(2):138-43.
[4]. Sun F, et al. Preclinical pharmacokinetic studies of 3-deazaneplanocin A, a potent epigenetic anticancer agent, and its human pharmacokinetic prediction using GastroPlus?. Eur J Pharm Sci. 2015 Sep 18;77:290-302.
[5]. Siddiqi FS, et al. The Histone Methyltransferase Enzyme Enhancer of Zeste Homolog 2 Protects against Podocyte Oxidative Stress and Renal Injury in Diabetes. J Am Soc Nephrol. 2016 Jul;27(7):2021-34.
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