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8-羟基喹啉,AR，99.0% 乙二胺四乙酸,AR 乙酸钾 双甘肽,99%
简介：MRS 2365是一种有效的选择性P2Y1受体激动剂，EC50为0.4nM。MRS2365在P2Y12或P2Y13受体上几乎没有激动剂或拮抗剂活性[1][2]。
MRS 2365物理化学性质：
分子式
C13H16N5Na3O9P2S
分子量
549.276
精确质量
548.984
PSA
276.78
LogP
1.5353
MRS 2365详细介绍：
英文名称：
MRS 2365
CAS号：
436847-09-5
分子式：
C13H16N5O9P2S-3.3[NA+]
分子量：
549.28
详细描述：
P2Y1受体激动剂,A highly potent, selective P2Y1 receptor agonist with EC50 of 1.2 nM.
化学名： [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt
生物活性：MRS 2365 is a highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS.
技术参数：
分子量549.28
公式 C13H16N5O9P2SNa3
储存 Store at -20°C
纯度 ≥98% (HPLC)
溶解性Soluble in water (supplied pre-dissolved at a concentration of 10mM)
外观 Colourless liquid
Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Storage Store at -20°C
参考文献
Ravi et al (2002) Adenine nucleotide analogues locked in a northern methanocarba conformation: enhanced stability and potency as P2Y1 receptor agonists. J.Med.Chem. 45 2090 PMID: 11985476
Chhatriwala et al (2004) Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J.Pharmacol.Exp.Ther. 311 1038 PMID: 15345752
Lu et al (2007) Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 323 157 PMID: 17626796
查询关键词：“436847-09-5，MRS 2365，PC10886，Medlife，上海现货”。
MRS 2365参考文献：
[1]. Mariya Chhatriwala, et al. Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43.
[2]. D M Bourdon, et al. (N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets. J Thromb Haemost. 2006 Apr;4(4):861-8.
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