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PBS磷酸盐缓冲液(20×) 三苯基硫氯甲烷,≥96% Regorafenib (BAY 73-4506) 1-氨基芘
简介：JQ1 compound是一种 BET bromodomain 抑制剂，抑制 BRD4(1/2) 的 IC50 分别为 77 nM 和 33 nM。
JQ1 compound物理化学性质：
密度
1.3±0.1 g/cm3
沸点
610.4±65.0 °C at 760 mmHg
分子式
C23H25ClN4O2S
分子量
456.988
闪点
322.9±34.3 °C
精确质量
456.138672
PSA
97.61
LogP
4.49
外观性状
white to beige
蒸汽压
0.0±1.7 mmHg at 25°C
折射率
1.657
储存条件
2-8°C
水溶解性
DMSO: soluble20mg/mL, clear
JQ1 compound详细介绍：
中文名称：
(S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂卓-6-基)乙酸叔丁酯
中文别名：
（+）-JQ1 抑制剂;(S)-(＋)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4];(S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂卓-6-基)乙酸叔丁酯;(S)-(+)-叔丁基 2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]噻唑并[4,3-a][1,4]二氮杂革-6-基)乙酸酯;(S)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂卓-6-基)乙酸叔丁酯;2,4-二氯呋喃并[3,2-D]嘧啶
英文名称：
JQ1 compound
英文别名：
(S)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(+)-JQ-1;(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4];(+)?-?JQ-?1;(＋)-JQ1;(S)-(+)-Tert-butyl 2;(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)aceta...;(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno-[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid,;JQ1;(6s)-6-(2-Tert-Butoxy-2-Oxoethyl)-4-(4-Chlorophenyl)-2,3,9-Trimethyl-6,7-Dihydrothieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepin-10-Ium;(S)-JQ1;3mxf;4flp;CHEMBL1957266;JQ-1;SureCN881227;UNII-1MRH0IMX0W;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-;JQ1 compound;Bromodomain Inhibitor, (+)-JQ1;1MRH0IMX0W;(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-6-yl)acetate;(S)-te
CAS号：
1268524-70-4
分子式：
C23N4O2SCLH25
分子量：
456.99
详细描述：
创赛优选提供1268524-70-4，Bromodomain Inhibitor, (+)-JQ1，Medlife，上海现货。
Medlife，致力于提供高品质、高性价比小分子化合物的产品。
Medlife小分子化合物大量库存，提供超过2万种的抑制剂、激动剂、拮抗剂等产品，是药物及疾病研究的重要原料供应商。
(+)-JQ-1 是一种 BET bromodomain 抑制剂，抑制 BRD4(1/2)，IC50 分别为 77 nM/33 nM。
查询关键词:“1268524-70-4，Bromodomain Inhibitor, (+)-JQ1，Medlife，上海现货”。
JQ1 compound参考文献：
[1]. Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
[2]. Matzuk MM, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150(4):673-84.
[3]. Peirs S, et al. Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia. Leukemia. 2017 Feb 3.
[4]. T?gel L, et al. Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. Mol Cancer Ther. 2016 Jun;15(6):1217-26.
[5]. Sahni JM, et al. Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases. J Biol Chem. 2016 Nov 4;291(45):23756-23768.
[6]. Nakamura Y, et al. Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway. Cancer Lett. 2017 Aug 28;402:100-109.
[7]. Bhattacharyya S, et al. Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways. Genome Res. 2017 Nov;27(11):1830-1842.
[8]. Lv B, et al. Enhancement of adenovirus infection and adenoviral vector-mediated gene delivery by bromodomain inhibitor JQ1. Sci Rep. 2018 Aug 1;8(1):11554. doi: 10.1038/s41598-018-28421-x.
[9]. Huang X, et al. Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors. Cell. 2018 Sep 20;175(1):186-199.e19. doi: 10.1016/j.cell.2018.08.058. Epub 2018 Sep 13.
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