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357400-13-6|NNC 55-0396，技术参数

2023-01-17

简介：NNC 55-0396是Mibefradil衍生物，是T型钙离子通道阻断剂。

NNC 55-0396物理化学性质：

沸点

713.8ºC at 760mmHg

分子式

C30H40Cl2FN3O2

分子量

564.562

闪点

385.5ºC

精确质量

563.248

PSA

58.22

LogP

7.6385

 

NNC 55-0396详细介绍：

中文名称：

1-溴-2-(二氟甲基)-4-氟苯

中文别名：

1-溴-2-(二氟甲基)-4-氟苯

英文名称：

NNC 55-0396

英文别名：

Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylester, hydrochloride (1:2);(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE;Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-...;Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-;NNC 55-0396 dihydrochloride;NNC 55-0396 dihydrochloride,(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylcyclopropanecarboxylatedihydrochloride;NNC 55-0396

CAS号：

357400-13-6

分子式：

C30H38FN3O2.2CLH

分子量：

564.56

详细描述：

创赛优选提供357400-13-6，NNC 55-0396，Medlife，上海现货。

Medlife，致力于提供高品质、高性价比小分子化合物的产品。

Medlife小分子化合物大量库存，提供超过2万种的抑制剂、激动剂、拮抗剂等产品，是药物及疾病研究的重要原料供应商。

T型钙离子通道阻断剂,NNC 55-0396是Mibefradil衍生物，是T型钙离子通道阻断剂。

查询关键词:“357400-13-6，NNC 55-0396，PC11878，Medlife，上海现货”。

 

NNC 55-0396参考文献：

[1]. Arnulfo Quesadaa, Peter H. Bui, Gregg E. Homanics，et al. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 2011,659 (1): 30-36.

[2]. Timo Strünker, Normann Goodwin, Christoph Brenker, et al. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature, 2011,471, 382-386.

[3]. Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto, et al. Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior. 2011,97(4): 656-659.

[4]. Li M, Hansen JB, Huang L, et al. Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. Cardiovasc Drug Rev. 2005 Summer;23(2):173-96.

[5]. Huang L, Keyser BM, Tagmose TM, et al. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9.

货号 产品名称 品牌 规格型号 包装 目录价 促销价 数量 购物车
PC11878 NNC 55-0396 ,357400-13-6 Medlife ≥98% 10mg ¥3622.08
PC11878 NNC 55-0396 ,357400-13-6 Medlife ≥98% 5mg ¥2538.20
A02-A3662 [APExBIO]NNC 55-0396,98% ,357400-13-6 APExBIO 98% 5mg ¥2726.00
A02-A3662 [APExBIO]NNC 55-0396,98% ,357400-13-6 APExBIO 98% 10mg ¥3890.00
PA70316 NNC 55-0396,≥98% ,357400-13-6 PERFEMIKER ≥98% 1mg ¥2138.00
PA70316 NNC 55-0396,≥98% ,357400-13-6 PERFEMIKER ≥98% 5mg ¥5227.00
MACKLIN-N879383 NNC 55-0396 ,357400-13-6 macklin ≥98% 1mg ¥472.00
MACKLIN-N879383 NNC 55-0396 ,357400-13-6 macklin ≥98% 5mg ¥1153.00
A-N274718 NNC 55-0396二盐酸盐 ,357400-13-6 Aladdin阿拉丁 ≥99% 25mg ¥4290.00
A-N274718 NNC 55-0396二盐酸盐 ,357400-13-6 Aladdin阿拉丁 ≥99% 5mg ¥1140.00
RHAWN-R112843 NNC 55-0396 ,357400-13-6 罗恩 ≥98% 1mg ¥453.00
RHAWN-R112843 NNC 55-0396 ,357400-13-6 罗恩 ≥98% 5mg ¥1107.00