Abemaciclib metabolite M18 hydrochloride

LSN3106729 hydrochloride （订货以CAS编码或英文名称为准）

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编号：PC21482

储存条件：4°C, sealed storage, away from moisture

申请试用

货号	品牌	规格	纯度/含量	标准价	优惠价	库存货期	数量	购买
PC21482-5mg	Medlife	5mg	99%	待询	登录后可见

英文名称：

LSN3106729 hydrochloride

详细描述

<p><span style="font-size: small;"><span style="color: #331515; font-family: Arial, sans-serif; text-align: justify;">Abemaciclib metabolite M18 (LSN3106729) hydrochloride，Abemaciclib 的代谢物，是一种具有抗肿瘤活性的 </span><span style="font-weight: bold; color: #331515; font-family: Arial, sans-serif; text-align: justify;">CDK</span><span style="color: #331515; font-family: Arial, sans-serif; text-align: justify;"> 抑制剂。Abemaciclib metabolite M18 hydrochloride 和 CRBN 配体可用于设计 PROTAC CDK4/6 降解剂。</span></span></p> <table class="details_info_tbl" style="border-width: 0px 0px 2px; border-top-style: initial; border-right-style: initial; border-bottom-style: solid; border-left-style: initial; border-top-color: initial; border-right-color: initial; border-bottom-color: #ebe4f6; border-left-color: initial; border-image: initial; margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; color: #331515; font-family: Arial, sans-serif; font-size: 12px; text-indent: 0px;"> <tbody> <tr><th class="details_info_th" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px 4px; text-align: center; width: 171px; color: #6a4b92; line-height: 20px; font-size: 14px; box-sizing: border-box;"><span style="font-size: small;">生物活性</span></th> <td class="details_info_td" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; width: 827px;"> <div style="padding: 15px 18px 13px;"> <p style="border: none; margin: 0px; padding: 0px; line-height: 20px; color: #331515; text-align: justify;"><span style="font-size: small;">Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a <span style="font-weight: bold;">CDK</span> inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader<sup style="bottom: 0px; position: relative; transform: scale(0.8); display: inline-block; line-height: 12px; font-size: 0.9em;"><a style="color: #6a4b92;">[1]</a></sup>.</span></p> </div> </td> </tr> <tr><th class="details_info_th" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px 4px; text-align: center; width: 171px; color: #6a4b92; line-height: 20px; font-size: 14px; box-sizing: border-box;"><span style="font-size: small;">IC<sub style="top: 0px; position: relative; transform: scale(0.8); display: inline-block; line-height: 12px; font-size: 0.9em; font-weight: normal;">50</sub> & Target<sup style="bottom: 0px; position: relative; transform: scale(0.8); display: inline-block; line-height: 12px; font-size: 0.9em; font-weight: normal;"><a>[1]</a></sup></span></th> <td class="details_info_td" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; width: 827px;"> <table id="pro-ic50-tbl" style="border: 0px; margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 827px;"> <tbody> <tr> <td class="ic50-td0" style="border: 0px; margin: 0px; padding: 0px; box-sizing: border-box;"> <p style="border-top: 0px; border-right: none; border-bottom: none; border-left: none; border-image: initial; margin: 0px; padding: 0px; line-height: 22px; box-sizing: border-box;"><span style="display: inline-block; padding: 8px 18px 6px; white-space: nowrap; box-sizing: border-box; font-size: small;">CDK4</span></p> </td> <td class="ic50-td0" style="border-width: 0px 0px 0px 1px; border-top-style: initial; border-right-style: initial; border-bottom-style: initial; border-left-style: solid; border-top-color: initial; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; box-sizing: border-box; width: 758.989px;"> <p style="border-top: 0px; border-right: none; border-bottom: none; border-left: none; border-image: initial; margin: 0px; padding: 0px; line-height: 22px; box-sizing: border-box;"><span style="display: inline-block; padding: 8px 18px 6px; white-space: nowrap; box-sizing: border-box; font-size: small;">CDK6</span></p> </td> </tr> </tbody> </table> </td> </tr> <tr><th class="details_info_th" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px 4px; text-align: center; width: 171px; color: #6a4b92; line-height: 20px; font-size: 14px; box-sizing: border-box;"><span style="font-size: small;">分子量</span></th> <td class="details_info_td" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; width: 827px;"> <div style="padding: 15px 18px 13px;"> <p id="molecularWeight" style="border: none; margin: 0px; padding: 0px; line-height: 20px; color: #331515; text-align: justify;"><span style="font-size: small;">531.00</span></p> </div> </td> </tr> <tr><th class="details_info_th" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px 4px; text-align: center; width: 171px; color: #6a4b92; line-height: 20px; font-size: 14px; box-sizing: border-box;"><span style="font-size: small;">Formula</span></th> <td class="details_info_td" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; width: 827px;"> <div style="padding: 15px 18px 13px;"> <p style="border: none; margin: 0px; padding: 0px; line-height: 20px; color: #331515; text-align: justify;"><span style="font-size: small;">C<sub style="top: 0px; position: relative; transform: scale(0.8); display: inline-block; line-height: 12px; font-size: 0.9em;">25</sub>H<sub style="top: 0px; position: relative; transform: scale(0.8); display: inline-block; line-height: 12px; font-size: 0.9em;">29</sub>ClF<sub style="top: 0px; position: relative; transform: scale(0.8); display: inline-block; line-height: 12px; font-size: 0.9em;">2</sub>N<sub style="top: 0px; position: relative; transform: scale(0.8); display: inline-block; line-height: 12px; font-size: 0.9em;">8</sub>O</span></p> </div> </td> </tr> <tr><th class="details_info_th" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px 4px; text-align: center; width: 171px; color: #6a4b92; line-height: 20px; font-size: 14px; box-sizing: border-box;"><span style="font-size: small;">运输条件</span></th> <td class="details_info_td" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; width: 827px;"> <div style="padding: 15px 18px 13px;"> <p style="border: none; margin: 0px; padding: 0px; line-height: 20px; color: #331515; text-align: justify;"><span style="font-size: small;">Room temperature in continental US; may vary elsewhere.</span></p> </div> </td> </tr> <tr><th class="details_info_th" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px 4px; text-align: center; width: 171px; color: #6a4b92; line-height: 20px; font-size: 14px; box-sizing: border-box;"><span style="font-size: small;">储存方式</span></th> <td class="details_info_td" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; width: 827px;"> <div id="details_storage" style="padding: 11px 18px 10px;"> <p style="border: none; margin: 0px; padding: 0px; line-height: 20px; color: #331515; text-align: justify;"><span style="font-size: small;">4°C, sealed storage, away from moisture</span></p> <p class="pro-info-remark" style="border: none; margin: 0px; padding: 0px; color: #7a7a7a; line-height: 20px; text-align: justify;"><span style="font-size: small;"><span style="color: #ee3134; margin-right: 11px;">*</span>In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)</span></p> </div> </td> </tr> <tr><th class="details_info_th" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px 4px; text-align: center; width: 171px; color: #6a4b92; line-height: 20px; font-size: 14px; box-sizing: border-box;"><span style="font-size: small;">溶解性数据</span></th> <td class="details_info_td" style="border-width: 0px 1px 1px; border-top-style: initial; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; border-top-color: initial; border-right-color: #ebe4f6; border-bottom-color: #ebe4f6; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; width: 827px;"> <div class="ss-title" style="padding: 6px 14px 3px; font-size: 14px; background-color: #f9f7fb; margin: 7px 6px 8px 5px; color: #6a4b92; font-weight: bold; line-height: 20px; font-style: italic;"><span style="font-size: small;">In Vitro: </span></div> <div class="ss-vitro" style="padding: 3px 18px 10px;"> <p style="border: none; margin: 0px; padding: 0px; line-height: 20px; color: #331515; text-align: justify;"><span style="font-size: small;"><span style="font-weight: bold;">DMSO : 125 mg/mL</span> (<span style="font-weight: bold;">235.40 mM</span><span style="font-weight: bold;">;</span> Need ultrasonic)</span></p> <p style="border: none; margin: 0px; padding: 0px; line-height: 20px; color: #331515; text-align: justify;"><span style="font-size: small;"><span style="font-weight: bold;">H<sub style="top: 0px; position: relative; transform: scale(0.8); display: inline-block; line-height: 12px; font-size: 0.9em; font-weight: normal;">2</sub>O : 100 mg/mL</span> (<span style="font-weight: bold;">188.32 mM</span><span style="font-weight: bold;">;</span> Need ultrasonic)</span></p> </div> <div id="stock-solution" style="padding: 0px; border-top: 1px solid #ebe4f6; border-bottom: 1px solid #ebe4f6; margin: 3px 18px 0px;"> <div style="display: table-cell; line-height: 20px; width: 135px; vertical-align: middle; text-align: center; font-weight: bold; font-size: 14px;"><span style="font-size: small;">配制储备液</span></div> <div style="display: table-cell; line-height: 20px;"> <table class="pss-hd" style="border: 0px; margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px;"> <tbody> <tr><th id="pss-thead" class="pss-tbl-w1" style="border-width: 0px 0px 0px 1px; border-top-style: initial; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: initial; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; text-align: center; width: 193px; position: relative; background: url('images/web/stock-solutions-hd-bg.png') no-repeat; box-sizing: border-box; height: 60px;"><span style="font-size: small;"><span id="ss-th-1" style="top: 39px; left: 18px; position: absolute;">浓度</span><span id="ss-th-2" style="top: 10px; left: 74px; position: absolute;">溶剂体积</span><span id="ss-th-3" style="top: 10px; left: 150px; position: absolute;">质量</span></span></th><th class="pss-tbl-w2" style="border-width: 0px 0px 0px 1px; border-top-style: initial; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: initial; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; text-align: center; width: 157px; box-sizing: border-box; height: 60px;"><span style="font-size: small;">1 mg</span></th><th class="pss-tbl-w3" style="border-width: 0px 0px 0px 1px; border-top-style: initial; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: initial; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; text-align: center; width: 157px; box-sizing: border-box; height: 60px;"><span style="font-size: small;">5 mg</span></th><th class="pss-tbl-w4" style="border-width: 0px 0px 0px 1px; border-top-style: initial; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: initial; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 0px; text-align: center; width: 157px; box-sizing: border-box; height: 60px;"><span style="font-size: small;">10 mg</span></th></tr> </tbody> </table> <table id="pss-content" style="border: 0px; margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px;"> <tbody> <tr> <td class="pss-tbl-w1" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 90px 1px 0px; text-align: right; width: 193px; box-sizing: border-box;"><span style="font-size: small;">1 mM</span></td> <td class="pss-tbl-w2" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 0px 1px; text-align: center; width: 157px; box-sizing: border-box;"><span style="font-size: small;">1.8832 mL</span></td> <td class="pss-tbl-w3" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 0px 1px; text-align: center; width: 157px; box-sizing: border-box;"><span style="font-size: small;">9.4162 mL</span></td> <td class="pss-tbl-w4" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 0px 1px; text-align: center; width: 157px; box-sizing: border-box;"><span style="font-size: small;">18.8324 mL</span></td> </tr> <tr> <td class="pss-tbl-w1" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 90px 1px 0px; text-align: right; width: 193px; box-sizing: border-box;"><span style="font-size: small;">5 mM</span></td> <td class="pss-tbl-w2" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 0px 1px; text-align: center; width: 157px; box-sizing: border-box;"><span style="font-size: small;">0.3766 mL</span></td> <td class="pss-tbl-w3" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 0px 1px; text-align: center; width: 157px; box-sizing: border-box;"><span style="font-size: small;">1.8832 mL</span></td> <td class="pss-tbl-w4" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 0px 1px; text-align: center; width: 157px; box-sizing: border-box;"><span style="font-size: small;">3.7665 mL</span></td> </tr> <tr> <td class="pss-tbl-w1" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 90px 1px 0px; text-align: right; width: 193px; box-sizing: border-box;"><span style="font-size: small;">10 mM</span></td> <td class="pss-tbl-w2" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 0px 1px; text-align: center; width: 157px; box-sizing: border-box;"><span style="font-size: small;">0.1883 mL</span></td> <td class="pss-tbl-w3" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 0px 1px; text-align: center; width: 157px; box-sizing: border-box;"><span style="font-size: small;">0.9416 mL</span></td> <td class="pss-tbl-w4" style="border-width: 1px 0px 0px 1px; border-top-style: dotted; border-right-style: initial; border-bottom-style: initial; border-left-style: dotted; border-top-color: #ebe4f6; border-right-color: initial; border-bottom-color: initial; border-left-color: #ebe4f6; border-image: initial; margin: 0px; padding: 8px 0px 1px; text-align: center; width: 157px; box-sizing: border-box;"><span style="font-size: small;">1.8832 mL</span></td> </tr> </tbody> </table> </div> </div> <div id="stock-solution-tips" style="padding: 11px 18px 10px;"><span class="red" style="color: #ee3134; float: left; padding-top: 4px; font-size: small;">*</span> <p style="border: none; margin: 0px 0px 0px 18px; padding: 0px; line-height: 20px; color: #331515; text-align: justify;"><span style="font-size: small;">请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，<span style="font-weight: bold;">请分装保存，避免反复冻融造成的产品失效</span>。</span><br /><span style="font-size: small;"><span style="font-weight: bold;">储备液的保存方式和期限：</span>-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。</span></p> </div> </td> </tr> </tbody> </table> <p> </p>

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