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DCPIB

DCPIB （订货以CAS编码或英文名称为准）

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编号：Cayman-34064
分子式：C22H28O4CL2
CAS号：82749-70-0
分子量：427.36
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货号 品牌 规格 纯度/含量 标准价 优惠价 库存货期 数量 购买
34064-10mg Cayman 10mg
N/A
 ¥1792.00 登录后可见
中文名称： 82749-70-0
英文名称： DCPIB
英文别名： DCPIB;4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid;4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoicacid;HMS3268C07
CAS号： 82749-70-0
分子式： C22H28O4CL2
分子量： 427.36
详细描述

DCPIB is an inhibitor of volume-regulated anion channels (VRAC).1 It inhibits the swelling-induced chloride current (ICl,swell) in bovine pulmonary artery endothelial cells (IC50 = 4.1 µM). DCPIB inhibits the VRAC subunit leucine-rich containing 8A (LRRC8A; IC50 = 20.9 µM) and inhibits sphingosine-1-phosphate-induced cGAMP uptake by LRRC8A in telomerase-immortalized human microvascular endothelial (TIME) cells when used at a concentration of 20 µM.2,3 It also inhibits the two-pore domain potassium channels K2P18.1/TRESK, K2P3.1/TASK1, and K2P9.1/TASK3 in COS-7 cells expressing the human channels (IC50s = 0.14, 0.95, and 50.72 µM, respectively).4 DCPIB (10 µM) activates K2P2.1/TREK1 and K2P4.1/TRAAK channels in COS-7 cells expressing the human channels. Intracisternal administration of DCPIB (20 µg/kg) reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).5

WARNING This product is not for human or veterinary use.
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