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HAMI3379

ent-Oseltamivir Phosphate （订货以CAS编码或英文名称为准）

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编号：Cayman-10580
分子式：C16H28N2O4.HO4P
CAS号：1245653-57-9
分子量：408.38
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货号 品牌 规格 纯度/含量 标准价 优惠价 库存货期 数量 购买
Cayman-10580-1mg Cayman 1mg
≥90%
 ¥742.00 登录后可见
Cayman-10580-5mg Cayman 5mg
≥90%
 ¥3234.00 登录后可见
Cayman-10580-10mg Cayman 10mg
≥90%
 ¥5754.00 登录后可见
Cayman-10580-25mg Cayman 25mg
≥90%
 ¥12544.00 登录后可见
中文名称： ent-奥塞米韦磷酸酯
中文别名： ent-奥塞米韦磷酸酯;(3S,4S,5R)-4-(乙酰氨基)-5-氨基-3-(1-乙基丙氧基)-1-环己烯-1-羧酸乙酯磷酸盐
英文名称： ent-Oseltamivir Phosphate
英文别名： ent-Oseltamivir Phosphate;ent-Oseltamivir Phos;(3S,4S,5R)-4-(AcetylaMino)-5-aMino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic Acid Ethyl Ester Phosphate
CAS号： 1245653-57-9
分子式： C16H28N2O4.HO4P
分子量： 408.38
详细描述

HAMI3379 is a cysteinyl leukotriene 2 (CysLT2) receptor antagonist (IC50 = 37.9 nM in a radioligand binding assay).1 It is selective for CysLT2 over CysLT1 (IC50 = >30 µM in a radioligand binding assay). HAMI3379 inhibits calcium mobilization induced by leukotriene D4 (LTD4; Item No. 20310) or leukotriene C4 (LTC4; Item No. 20210) in CHO cells expressing human CysLT2 (IC50s = 3.8 and 4.4 nM, respectively). It reverses the LTC4-induced increases in perfusion pressure and decreases in contractility in isolated Langendorff-perfused guinea pig hearts in a concentration-dependent manner. HAMI3379 (0.1 mg/kg) prevents decreases in body weight and neurological deficit scores in a rat model of S. pneumoniae-induced meningitis, as well as reduces infarct volume in a rat model of cerebral ischemia brain injury induced by middle cerebral artery occlusion (MCAO).2,3 It also prevents increases in airway hyperresponsiveness in a mouse model of ovalbumin-induced asthma when administered at a dose of 10 mg/kg.4
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