菲律平

Filipin （订货以CAS编码或英文名称为准）

创赛科技提供的所有产品仅用于科研等非医疗用途，非药品不可食用，不可用于人体或动物的临床诊断和治疗,我们不为个人提供产品及服务。如您需要产品COA等资料，可至下方“质量控制”中下载

编号：abs42018484

分子式：C35H58O11

CAS号：480-49-9

分子量：654.83

申请试用

货号	品牌	规格	纯度/含量	标准价	优惠价	库存货期	数量	购买
abs42018484-500ug	爱必信	500ug	N/A	¥1502.00	登录后可见

中文名称：

菲律平

中文别名：

菲律平;菲律宾菌素 III;菲律宾菌素

英文名称：

Filipin

英文别名：

Filipin;Filipin III;14-Deoxylagosin;15-Deoxylagosin;1',26-Dihydroxyfilipin I;1'-Hydroxyfilipin II;1'-epi-Filipin IV;Filimarisin;NSC 3364;NSC 38092

CAS号：

480-49-9

分子式：

C35H58O11

分子量：

654.83

详细描述

描述	Filipin III is a pentaene macrolide antibiotic and the predominant isomer of four isomeric polyene macrolides isolated from cultures of S. filipinensis. Due to Filipin III’s ability to fluoresce and bind to cholesterol, the compound has been used to detect cholesterol in membranes through freeze fracture electron microscopy and through decreased fluorescence of Filipin III upon binding. The compound has also been used in tobacco cells and observed to activate ligand-independent signaling responses. Through Filipin III’s cholesterol sequestering activity, the compound was able to disrupt the lipid rafts in both normal and transformed keratinocytes resulting in inhibition of the AKT pathway.
应用	A cholesterol-binding, fluorescing antibiotic
纯度	>90%
储存/保存方法	Store at -20° C，2 years.
基本信息
别名	菲律宾菌素；菲律平III; filimarisin
外观	A crystalline solid
可溶性/溶解性	DMSO: 10 mg/ml
参考文献
参考文献	1. Severs, N.J., et al. 1983. Biochim. Biophys. Acta. 737: 373-408. PMID: 6349687 2. Miller, R.G. 1984. Cell Biol. Int. Rep. 8: 519-535. PMID: 6378397 3. Castanho, M.A., et al. 1992. J. Biol. Chem. 267: 204-209. PMID: 1730589 4. Bonneau, L., et al. 2010. Biochim. Biophys. Acta. 1798: 2150-2159. PMID: 20674542 5. Calay, D., et al. 2010. J. Invest. Dermatol. 130: 1136-1145. PMID: 20054340

搜索质检报告(COA)